New analysis indicates that the benefits of a dietary compound on kidney health could rely upon a person’s genetics. The findings, which seem in a future problem of JASN, could also be useful for tailoring interventions to prevent or treat kidney disease. Glutathione S-transferase mu-1 (GSTM1) is an enzyme that performs a job in ridding the body of toxins and combatting oxidative stress. Many people carry a variant in the GSTM1 gene that stops the gene’s expression (referred to as a null variant), and due to this fact, they lack the production of the enzyme. A team led by Thu H. Le, MD (College of Rochester Medical Center) previously confirmed that people carrying this variant face the next risk of experiencing kidney function decline.
Of their latest examine, the investigators discovered that the deletion of the gene increases kidney harm in mice with hypertension and kidney disease. Supplementing the diet with broccoli powder (which is rich in an antioxidant-activating compound) considerably lessened kidney injury within the genetically altered mice, however not in regular mice with kidney disease.
“We speculate that the GSTM1 enzyme could also be concerned within the breakdown of antioxidant-selling compounds, and subsequently deficiency within the enzyme might improve the bioavailability of protecting compounds related to kidney disease,” mentioned Dr. Le. When the researchers examined info from a big scientific trial, they discovered that prime consumption of broccoli and different cruciferous greens was linked with a decrease danger of kidney failure, primarily in contributors with the GSTM1 null variant.
Moreover, our examine means that understanding a person’s genetic info permits tailoring an intervention to forestall or delay kidney disease development amongst those that would reply primarily based on their genetic make-up.”